Indocyanine green-loaded porphyrin covalent organic frameworks for photothermal cancer therapy

Author:

Tong Simiao1,Li Cheng1,Wang Kai2,Wu Fengshou1ORCID

Affiliation:

1. Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Key Laboratory of Novel Biomass-Based Environmental and Energy Materials in Petroleum and Chemical Industry, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430072, P. R. China

2. Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, People's Republic of China

Abstract

A porphyrin-based covalent organic framework was synthesized as a platform for loading of indocyanine green. The resulting composites (ICG@COF NPs) exhibited enhanced photostability and superior photothermal effect, which demonstrated remarkable efficacy in tumor ablation in vivo.

Funder

National Natural Science Foundation of China

Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Materials Science

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