The convergent total synthesis and antibacterial profile of the natural product streptothricin F-Reference-Cited by-同舟云学术

The convergent total synthesis and antibacterial profile of the natural product streptothricin F

Published:2022 Issue:12 Volume:13 Page:3447-3453
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Dowgiallo Matthew G.¹^ORCID,Miller Brandon C.¹^ORCID,Kassu Mintesinot¹,Smith Kenneth P.²³,Fetigan Andrew D.¹,Guo Jason J.¹⁴⁵,Kirby James E.²³^ORCID,Manetsch Roman¹⁶⁴^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA

2. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA

3. Harvard Medical School, Boston, MA, USA

4. Center for Drug Discovery, Northeastern University, Boston, MA, USA

5. Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, MA, USA

6. Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA

Abstract

The second ever total synthesis of streptothricin F and the first achieved through a diversity-enabling convergent route. The synthesis is achieved in 35 total steps, with a longest linear sequence of 19 steps, and 0.40% overall yield.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC06445B

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