Efficient and regioselective synthesis of <i>ortho</i>-diiodinated homobenzylic alcohol derivatives: <i>in silico</i> evaluation as potential anticancer IDO/TDO inhibitors-Reference-Cited by-同舟云学术

Efficient and regioselective synthesis of ortho-diiodinated homobenzylic alcohol derivatives: in silico evaluation as potential anticancer IDO/TDO inhibitors

Published:2024 Issue: Volume: Page:
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Al-Zoubi Raed M.¹²³^ORCID,Al-Jammal Walid K.³^ORCID,Shkoor Mohanad⁴^ORCID,Bani-Yaseen Abdulilah D.⁴,Khan Abbas⁵,Agouni Abdelali⁵^ORCID,McDonald Robert⁶^ORCID

Affiliation:

1. Department of Biomedical Sciences, QU-Health, College of Health Sciences, Qatar University, Doha, 2713, Qatar

2. Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar

3. Department of Chemistry, Jordan University of Science and Technology, P.O.Box 3030, Irbid, 22110, Jordan

4. Department of Chemistry and Earth Sciences, Qatar University, P.O. Box 2713, Doha, Qatar

5. Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar

6. Department of Chemistry, Gunning-Lemieux Chemistry Centre, University of Alberta, Edmonton, Alberta, T6G2G2, Canada

Abstract

A direct and highly regioselective method for synthesizing 2,6-diiodophenylethanol is presented. In silico analysis shows compounds 7a, 7p, 7t, and 7z interact favourably with IDO/TDO receptors, highlighting their unmatched anticancer potential.

Funder

Jordan University of Science and Technology

Hamad Medical Corporation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB01076K

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