A platinum(iv) prodrug to defeat breast cancer through disrupting vasculature and inhibiting metastasis
Author:
Affiliation:
1. State Key Laboratory of Coordination Chemistry
2. School of Chemistry and Chemical Engineering
3. Nanjing University
4. Nanjing 210023
5. P. R. China
6. State Key Laboratory of Pharmaceutical Biotechnology
7. School of Life Sciences
Abstract
A PtIV prodrug bearing a vascular disrupting agent demonstrates antiangiogenic and antimetastatic potentialities against metastatic triple-negative breast cancer cells.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
National Basic Research Program of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/DT/C9DT00335E
Reference33 articles.
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4. Hyperthermia-mediated drug delivery induces biological effects at the tumor and molecular levels that improve cisplatin efficacy in triple negative breast cancer
5. Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
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