Conformational analysis of amphetamine and methamphetamine: a comprehensive approach by vibrational and chiroptical spectroscopy

Author:

Dobšíková Kristýna1ORCID,Michal Pavel2ORCID,Spálovská Dita1ORCID,Kuchař Martin345ORCID,Paškanová Natalie34ORCID,Jurok Radek346ORCID,Kapitán Josef2ORCID,Setnička Vladimír1ORCID

Affiliation:

1. Department of Analytical Chemistry, University of Chemistry and Technology, Prague 6, 166 28, Czech Republic

2. Department of Optics, Palacký University Olomouc, Olomouc, 771 46, Czech Republic

3. Forensic Laboratory of Biologically Active Substances, University of Chemistry and Technology, Prague 6, 166 28, Czech Republic

4. Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Prague 6, 166 28, Czech Republic

5. National Institute of Mental Health, Klecany 250 67, Czech Republic

6. Department of Organic Chemistry, University of Chemistry and Technology, Prague 6, 166 28, Czech Republic

Abstract

We present the first comprehensive structural study of amphetamine and its derivatives in aqueous solution performed by the methods of VCD, ROA, IR, and Raman spectroscopy including a successful conformational analysis of studied compounds.

Funder

Grantová Agentura České Republiky

Univerzita Palackého v Olomouci

Ministerstvo Vnitra České Republiky

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference66 articles.

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4. European Monitoring Centre for Drugs and Drug Addiction , European drug report 2018: trends and developments , Office of the European Union , Luxembourg , 2019

5. European Monitoring Centre for Drugs and Drug Addiction , European drug report 2018: trends and developments , Office of the European Union , Luxembourg , 2020

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