pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment

Author:

Lee Junmin1234,Wang Yonggang345,Xue Chengbin3467,Chen Yi348ORCID,Qu Moyuan34,Thakor Jai34,Zhou Xingwu34,Barros Natan Roberto1,Falcone Natashya1,Young Patric1,van den Dolder Floor W.34,Lee KangJu1349,Zhu Yangzhi1,Cho Hyun-Jong3410ORCID,Sun Wujin134ORCID,Zhao Bo8,Ahadian Samad134,Jucaud Vadim1,Dokmeci Mehmet R.134,Khademhosseini Ali134ORCID,Kim Han-Jun134ORCID

Affiliation:

1. Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA

2. Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea

3. Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA

4. Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA 90095, USA

5. Guangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, P. R. China

6. Key Laboratory of Neuroregeneration, Ministry of Education and Jiangsu Province, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, 226001, P.R. China

7. Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China

8. Department of Research and Design, Beijing Biosis Healing Biological Technology Co., Ltd, Daxing District, Biomedical Base, Beijing 102600, P. R. China

9. Department of Healthcare and Biomedical Engineering, Chonnam National University, Yeosu 59626, Republic of Korea

10. College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea

Abstract

Injectable shear-thinning biomaterials (STBs) have attracted significant attention because of their efficient and localized delivery of cells as well as various molecules ranging from growth factors to drugs.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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