PDAC-on-chip for in vitro modeling of stromal and pancreatic cancer cell crosstalk

Author:

Sgarminato Viola12,Marasso Simone Luigi34ORCID,Cocuzza Matteo345,Scordo Giorgio3,Ballesio Alberto3,Ciardelli Gianluca156,Tonda-Turo Chiara15ORCID

Affiliation:

1. Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy

2. Department of Surgical Sciences, Università degli Studi di Torino, Corso Dogliotti, 14, 10126 Torino, Italy

3. Chilab – Materials and Microsystems Laboratory, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Chivasso, TO, Italy

4. CNR-IMEM, Parco Area delle Scienze, Parma, Italy

5. POLITO BIOMedLAB, Politecnico di Torino, Turin, Italy

6. Department for Materials and Devices of the National Research Council, Institute for the Chemical and Physical Processes (CNR-IPCF UOS), Pisa, Italy

Abstract

Schematic representation of PDAC-on-chip reassembly the pancreatic acino-ductal unit composed of healthy and pathological human pancreatic ductal epithelial cells (HPDE and KRAS-HPDE, respectively) surrounded by pancreatic stellate cells (PSCs).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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