A living neutrophil Biorobot synergistically blocks multifaceted inflammatory pathways in macrophages to effectively neutralize cytokine storm

Author:

Gao Ya1,Zhou Anwei2,Chen Kerong1,Zhou Xinyuan1,Xu Yurui1,Wu Shuangshuang3,Ning Xinghai1ORCID

Affiliation:

1. National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures, Chemistry and Biomedicine Innovation Center, College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing 210093, China

2. National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures, School of Physics, Nanjing University, Nanjing 210093, China

3. Jiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China

Abstract

A smart neutrophil neutralizer is developed for alleviating hyperinflammatory cytokine storm through simultaneously inhibiting multiple inflammatory pathways in macrophages.

Funder

National Key Research and Development Program of China

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Nanjing University

Jiangsu Provincial Department of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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