Synthesis and evaluation of bifunctional DFO2K: a modular chelator with ideal properties for zirconium-89 chelation

Author:

Salih Akam K.1,Khozeimeh Sarbisheh Elaheh2,Raheem Shvan J.1,Dominguez-Garcia Moralba1,Mehlhorn Hillary H.1,Price Eric W.1ORCID

Affiliation:

1. Department of Chemistry, College of Arts and Science, University of Saskatchewan, Saskatoon, SK, 110 Science Place, S7N-5C9, Canada

2. Life Sciences Division, TRIUMF, Vancouver, BC, Canada

Abstract

The synthesis and evaluation of the newest generation of our DFO2 chelator family—DFO2K—is described, including Zirconium-89 radiolabeling and stability assays.

Funder

Canada Research Chairs

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

Saskatchewan Health Research Foundation

Institute of Cancer Research

University of Saskatchewan

Publisher

Royal Society of Chemistry (RSC)

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