A glutathione-activated carrier-free nanodrug of triptolide as a trackable drug delivery system for monitoring and improving tumor therapy

Author:

Li Ying12345,Zhou Lihua678910ORCID,Zhu Baode11121314,Xiang Jingjing678910,Du Jian1516175,He Manwen1819205,Fan Xingxing2122232414,Zhang Pengfei678910ORCID,Zeng Ruosheng12345,Gong Ping678910

Affiliation:

1. School of Materials Science and Engineering

2. School of Life and Environmental Sciences

3. Guilin University of Electronic Technology

4. Guilin 541004

5. P. R. China

6. Guangdong Key Laboratory of Nanomedicine

7. Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations

8. CAS Key Lab for Health Informatics

9. CAS-HK Joint Lab for Biomaterials

10. Institute of Biomedicine and Biotechnology

11. College of Chemistry Biology & and Environmental Engineering

12. Xiangnan University

13. Chenzhou

14. China

15. Department of Urology

16. The First Affiliated Hospital of Shandong First Medical University, No. 16766

17. Jingshi Road, Jinan 250000

18. School of Applied Biology

19. Shenzhen Institute of Technology

20. Shenzhen 518116

21. State Key Laboratory of Quality Research in Chinese Medicine

22. Macau Institute for Applied Research in Medicine and Health

23. Macau University of Science and Technology

24. Macau

Abstract

The chemical structure of CyssTP and its self-assembly into a glutathione-activated carrier-free nanodrug of triptolide (CyssTPN) as a trackable drug delivery system for tumor therapy.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Chinese Academy of Sciences

Shenzhen Institutes of Advanced Technology Innovation Program for Excellent Young Researchers

Natural Science Foundation of Guangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Materials Science

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