A ratiometric fluorescent probe for real-time monitoring of intracellular glutathione fluctuations in response to cisplatin-Reference-Cited by-全球学者库

A ratiometric fluorescent probe for real-time monitoring of intracellular glutathione fluctuations in response to cisplatin

Published:2020 Issue:32 Volume:11 Page:8495-8501
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Hanzhuang¹²³⁴⁵^ORCID,Song Wenting¹²³⁴⁵,Zhang Shuren¹²³⁴⁵,Chan Kin Shing¹²³⁴⁵,Guo Zijian¹²³⁴⁵^ORCID,Shen Zhen¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Coordination Chemistry

2. School of Chemistry and Chemical Engineering

3. Nanjing University

4. Nanjing

5. China

Abstract

Real-time imaging of intracellular glutathione in response to cisplatin by a ratiometric fluorescent probe reveals that the different trends in intracellular GSH levels is crucial in distinguishing cisplatin-resistant from cisplatin-sensitive cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC02889D

Reference22 articles.

1. A near-infrared reversible fluorescent probe for real-time imaging of redox status changes in vivo

2. Glutathione: new roles in redox signaling for an old antioxidant

3. The Role of Sulfur in Platinum Anticancer Chemotherapy

4. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

5. Is Glutathione the Major Cellular Target of Cisplatin? A Study of the Interactions of Cisplatin with Cancer Cell Extracts

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