Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients-Reference-Cited by-同舟云学术

Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients

Published:2019 Issue:20 Volume:19 Page:3461-3471
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Ayuso Jose M.¹²³⁴⁵^ORCID,Virumbrales-Munoz Maria⁴⁵²³⁶,McMinn Patrick H.⁴⁵²³⁶^ORCID,Rehman Shujah¹²³⁴⁵,Gomez Ismael⁷⁸⁹¹⁰¹¹,Karim Mohammad R.¹²³⁴⁵,Trusttchel Regan⁴⁵²³⁶,Wisinski Kari B.⁴⁵²³⁶,Beebe David J.⁴⁵²³⁶,Skala Melissa C.¹²³⁴⁵

Affiliation:

1. Morgridge Institute for Research

2. Madison

3. USA

4. Department of Biomedical Engineering

5. University of Wisconsin

6. The University of Wisconsin Carbone Cancer Center

7. Allergy research group

8. IdISSC

9. San Carlos Clinic Hospital

10. Madrid

11. Spain

Abstract

Limited blood supply and rapid tumor metabolism within solid tumors leads to nutrient starvation, waste product accumulation and the generation of pH gradients across the tumor mass.

Funder

University of Wisconsin Carbone Cancer Center

National Institutes of Health

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/LC/C9LC00270G

Reference40 articles.

1. Influence of tumour micro-environment heterogeneity on therapeutic response