Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

Author:

Zhang Ruiping12345,Xu Yuling12345,Zhang Yi12345,Kim Hyeong Seok6789,Sharma Amit6789,Gao Jing1011121314,Yang Guangfu12345,Kim Jong Seung6789ORCID,Sun Yao12345ORCID

Affiliation:

1. Key Laboratory of Pesticides and Chemical Biology

2. Ministry of Education

3. International Joint Research Center for Intelligent Biosensor Technology and Health

4. Center of Chemical Biology

5. College of Chemistry

6. Department of Chemistry

7. Korea University

8. Seoul 02841

9. Korea

10. Jiangsu Key Laboratory of Medical Optics

11. Suzhou Institute of Biomedical Engineering and Technology

12. Chinese Academy of Sciences

13. Suzhou215163

14. China

Abstract

Theranostic nanoprobes (SYL NPs) prepared from a newly designed NIR-II fluorophore and FDA approved DSPE-mPEG5000 were well tolerated and exhibited multifunctional potential in diagnosis (photoacoustic & fluorescence imaging) and phototherapy in animal models.

Funder

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Central China Normal University

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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