Engineering enzymes for noncanonical amino acid synthesis-Reference-Cited by-同舟云学术

Engineering enzymes for noncanonical amino acid synthesis

Published:2018 Issue:24 Volume:47 Page:8980-8997
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Almhjell Patrick J.¹²³⁴^ORCID,Boville Christina E.¹²³⁴^ORCID,Arnold Frances H.¹²³⁴^ORCID

Affiliation:

1. Division of Chemistry and Chemical Engineering 210-41

2. California Institute of Technology

3. Pasadena

4. USA

Abstract

This tutorial review covers contemporary case studies of successful protein engineering to provide new noncanonical amino acid synthases, with emphasis on methods, outcomes, and mechanistic insights.

Funder

Resnick Sustainability Institute for Science, Energy and Sustainability, California Institute of Technology

California Institute of Technology

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CS/C8CS00665B

Reference50 articles.

1. Unusual Amino Acids in Medicinal Chemistry

2. Organic synthesis provides opportunities to transform drug discovery

3. Playing with the Molecules of Life

4. Enzymatic asymmetric synthesis of chiral amino acids

5. Computational redesign of enzymes for regio- and enantioselective hydroamination

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