Evaluation of the anticancer activities with various ligand substituents in Co(ii/iii)-picolyl phenolate derivatives: synthesis, characterization, DFT, DNA cleavage, and molecular docking studies

Author:

Jana Abhimanyu12,Aher Abhishek34,Brandao Paula5ORCID,Bera Pradip16,Sharda Saphy34,Phadikar Ujjwal1,Manna Sunil Kumar37,Mahapatra Ajit Kumar2,Bera Pulakesh1ORCID

Affiliation:

1. Post Graduate Department of Chemistry, Panskura Banamali College (Autonomous) (Vidyasagar University), Panskura R. S, Midnapore (East), West Bengal, 721152, India

2. Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, West Bengal, 711103, India

3. Centre for DNA Fingerprinting & Diagnostics (CDFD), Hyderabad, 500 039, Telangana, India

4. Graduate Studies, Regional Centre for Biotechnology, Faridabad, Haryana-121001, India

5. Department of Chemistry, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal

6. Department of Chemistry, Kandi Raj College, Murshidabad, West Bengal, 742137, India

7. Adjunct Faculty, Regional Centre for Biotechnology, Faridabad, Haryana, 121001, India

Abstract

Four mononuclear cobalt(ii/iii) complexes have been synthesized and structurally characterized using four different pyridine-phenolate based ligands for their apoptotic induction in human cancer cell.

Funder

Council of Scientific and Industrial Research

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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