A new sensitive UPLC-MS/MS method for the determination of cucurbitacin B in rat plasma: application to an absolute bioavailability study-Reference-Cited by-同舟云学术

A new sensitive UPLC-MS/MS method for the determination of cucurbitacin B in rat plasma: application to an absolute bioavailability study

Published:2018 Issue:54 Volume:8 Page:30978-30985
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xiao Ya¹²³⁴,Zhao Qiang¹²³⁴,Wu Qian¹²³⁴,Chang Jinhua¹²³⁴,Xue Hefei¹²³⁴,Liu Cuizhe¹²³⁴,Liu Xigang¹²³⁴^ORCID

Affiliation:

1. Hebei Key Laboratory of Research and Development for Chinese Medicine

2. Chengde Medical University

3. Chengde

4. P. R. China

Abstract

A method was developed for the determination of CuB in plasma using UPLC-MS/MS with estrone as an internal standard, and the pharmacokinetics and absolute bioavailability of CuB in rats were examined.

Funder

Chengde Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA05941A

Reference21 articles.

1. Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation

2. Cucurbitacins from Bacopa monnieri☆

3. Cucurbitacins and cucurbitane glycosides: structures and biological activities

4. The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer

5. Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562

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