Novel pyridinium oximes: synthesis, molecular docking and in vitro reactivation studies
Author:
Affiliation:
1. Division of Cyclotron and Radiopharmaceutical Sciences
2. Institute of Nuclear Medicine and Allied Sciences
3. Delhi-110054
4. India
5. Department of Chemistry
6. University of Delhi
Abstract
A computational approach has been attempted for the screening of 4-pyridoxinium (4P) ring based reactivators for paraoxon inhibited AChE.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA14696D
Reference31 articles.
1. Peripheral site ligand–oxime conjugates: A novel concept towards reactivation of nerve agent-inhibited human acetylcholinesterase
2. Centrally acting oximes in reactivation of tabun-phosphoramidated AChE
3. Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents
4. Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
5. Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
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