New pyrazolo[3,4-d]pyrimidine derivatives as EGFR-TK inhibitors: design, green synthesis, potential anti-proliferative activity and P-glycoprotein inhibition

Author:

Hassaballah Aya I.1ORCID,AboulMagd Asmaa M.2ORCID,Hemdan Magdy M.1,Hekal Mohamed H.1ORCID,El-Sayed Amira A.1,Farag Paula S.1

Affiliation:

1. Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt

2. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt

Abstract

In this work, compound 16 was synthesized and evaluated aganist EGFR with IC50 = 0.034 μM with potential P-glycoprotein inhibition.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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