One-pot synthesis of hollow PDA@DOX nanoparticles for ultrasound imaging and chemo-thermal therapy in breast cancer

Author:

Zhang Tao1234,Jiang Zhenqi56789,Xve Ting56789,Sun Shan56789,Li Juan56789ORCID,Ren Wenzhi56789,Wu Aiguo56789ORCID,Huang Pintong1234ORCID

Affiliation:

1. Department of Ultrasound in Medicine

2. The Second Affiliated Hospital of Zhejiang University School of Medicine

3. Hangzhou 310009

4. P.R. China

5. Cixi Institute of Biomedical Engineering

6. CAS Key Laboratory of Magnetic Materials and Devices

7. & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province

8. Ningbo Institute of Materials Technology and Engineering

9. Chinese Academy of Sciences

Abstract

A one-pot synthesis of hollow nanoparticles (PDA@DOX) used for breast cancer treatment with an extremely high drug loading rate and dual stimuli-responsive drug delivery capacity. PDA@DOX demonstrated good photothermal performance and ultrasound imaging capability.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Chinese Academy of Sciences

Natural Science Foundation of Ningbo

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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