Derivatization-assisted immunoassays: application for group-specific detection of potent methamphetamine and amphetamine enantiomers

Author:

Morita Izumi1ORCID,Kiguchi Yuki1ORCID,Oyama Hiroyuki1ORCID,Yamaki Kouya1,Sakio Nami1,Kashiwabara Keisuke1,Kuroda Yumi1,Ito Aya1,Yokota Asaka1,Ikeda Natsumi1,Kikura-Hanajiri Ruri2,Ueda Hiroshi3ORCID,Numazawa Satoshi4,Yoshida Takemi45,Kobayashi Norihiro1ORCID

Affiliation:

1. Kobe Pharmaceutical University, 4-19-1, Motoyama-Kitamachi, Higashinada-ku, Kobe 658-8558, Japan

2. National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan

3. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, 226-8503, Japan

4. Department of Pharmacology, Toxicology, and Therapeutics, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

5. Council on Pharmacists Credentials, 1-9-2 Nishi-shinbashi, Minato-ku, Tokyo 105-0003, Japan

Abstract

Chemical derivatization into larger molecules has generated a monoclonal antibody that enables group-specific immunochemical detection of potent methamphetamine and amphetamine enantiomers.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Reference50 articles.

1. R.Waters , Methamphetamine & Other Amphetamines , Mason Crest , Folcroft, PA, USA , 2014

2. J.Perritano , Stimulants: Meth, Cocaine, and Amphetamines , Mason Crest , Folcroft, PA, USA , 2016

3. Disappearance of R/S-methamphetamine and R/S-amphetamine from human scalp hair after discontinuation of methamphetamine abuse

4. Stereoselectivity in the human metabolism of methamphetamine

5. Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats

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