1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity-Reference-Cited by-同舟云学术

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1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity

Published:2021 Issue:25 Volume:45 Page:11136-11152
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

El-Shershaby Mohamed H.¹²³⁴⁵,Ghiaty Adel¹²³⁴⁵,Bayoumi Ashraf H.¹²³⁴⁵,Ahmed Hany E. A.¹²³⁴⁵,El-Zoghbi Mona S.⁶⁷⁸⁵,El-Adl Khaled⁹³⁴⁵¹⁰^ORCID,Abulkhair Hamada S.¹²³⁴⁵^ORCID

Affiliation:

1. Pharmaceutical Organic Chemistry Department

2. Faculty of Pharmacy

3. Al-Azhar University

4. Cairo

5. Egypt

6. Pharmaceutical Chemistry Department, Faculty of Pharmacy

7. Menoufia University

8. Shebin El-Koum

9. Department of Medicinal Chemistry & Drug Design, Faculty of Pharmacy

10. Department of Pharmaceutical Chemistry

Abstract

Targeting PCAF with small inhibitor molecules has emerged as a potential therapeutic strategy for the treatment of cancer.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ00710F

Reference52 articles.

1. Histone Modifications and Cancer

2. Histone Modifications and their Role in Colorectal Cancer (Review)

3. Keep-ING balance: Tumor suppression by epigenetic regulation

4. The bromodomain interaction module

5. Bromodomains as therapeutic targets

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