Immunogenicity and cytotoxicity of a platinum(iv) complex derived from capsaicin

Author:

Sun Yuewen12345,Yin Enmao12345,Tan Yehong12345,Yang Tao12345,Song Dongfan67345,Jin Suxing67345ORCID,Guo Zijian67345ORCID,Wang Xiaoyong12345ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology

2. School of Life Sciences

3. Nanjing University

4. Nanjing 210023

5. P. R. China

6. State Key Laboratory of Coordination Chemistry

7. School of Chemistry and Chemical Engineering

Abstract

A platinum(iv) complex DCP acts as a chemoimmunotherapeutic agent and induces cancer cell death by damaging DNA, stimulating immunogenic response, and enhancing phagocytosis.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference42 articles.

1. X. Y. Wang and Z. J.Guo , New Trends and Future Developments of Platinum-Based Antitumor Drugs , in Bioinorganic Medicinal Chemistry , ed. E. Alessio , Wiley-VCH Verlag GmbH & Co. KGaA , Weinheim , 2011 , pp. 97–149

2. Stimuli-Responsive Therapeutic Metallodrugs

3. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

4. Targeting and delivery of platinum-based anticancer drugs

5. Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

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