Synthesis and biological evaluation of coumarin–1,2,3-triazole–dithiocarbamate hybrids as potent LSD1 inhibitors
Author:
Affiliation:
1. New Drug Research & Development Center
2. School of Pharmaceutical Sciences
3. Zhengzhou University
4. Zhengzhou 450001, P.R. China
5. School of Pharmacy
6. Xinxiang Medical University
7. Xinxiang 453003, P.R. China
Abstract
Design of novel coumarin–1,2,3-triazole–dithiocarbamate hybrids as potent LSD1 inhibitors by introducing a coumarin scaffold.
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00031E
Reference25 articles.
1. Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
2. p53 is regulated by the lysine demethylase LSD1
3. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
4. Lysine Methylation Regulates E2F1-Induced Cell Death
5. Lysine-Specific Histone Demethylase 1 Inhibitors Control Breast Cancer Proliferation in ERα-Dependent and -Independent Manners
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