Guavinoside B from<i>Psidium guajava</i>alleviates acetaminophen-induced liver injury<i>via</i>regulating the Nrf2 and JNK signaling pathways-Reference-Cited by-同舟云学术

Guavinoside B fromPsidium guajavaalleviates acetaminophen-induced liver injuryviaregulating the Nrf2 and JNK signaling pathways

Published:2020 Issue:9 Volume:11 Page:8297-8308
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Yuanyuan¹²³⁴⁵,Xu Jialin⁶²³⁷⁵^ORCID,Li Dongli⁸⁹¹⁰⁵,Ma Hang¹¹¹²¹³¹⁴¹⁵^ORCID,Mu Yu¹²³⁴⁵,Huang Xueshi¹²³⁴⁵^ORCID,Li Liya¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Microbial Pharmaceuticals

2. College of Life and Health Sciences

3. Northeastern University

4. Shenyang 110819

5. P. R. China

6. Institute of Biochemistry and Molecular Biology

7. Shenyang

8. School of Biotechnology and Health Sciences

9. Wuyi University

10. Jiangmen 529020

11. Bioactive Botanical Research Laboratory

12. Department of Biomedical and Pharmaceutical Sciences

13. College of Pharmacy

14. University of Rhode Island

15. Kingston

Abstract

GUB, a main phenolic compound present in guava fruits, could alleviate APAP-induced liver injuryin vitroandin vivoby activating the Nrf2 signaling pathway and inhibiting the JNK signaling pathway.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Department of Education of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2020/FO/D0FO01338B

Reference50 articles.

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4. c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

5. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

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