Copper(<scp>ii</scp>)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm-Reference-Cited by-同舟云学术

Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm

Published:2024 Issue:5 Volume:12 Page:1317-1329
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Zhang Yaoxin¹,Li Linpei¹,Liu Hui²,Zhang Haixia¹,Wei Menghao¹,Zhang Junqing¹³,Yang Yanwei⁴,Wu Mengnan⁵,Chen Zhaowei⁵,Liu Chaoqun¹⁴^ORCID,Wang Faming⁶,Wu Qiang¹^ORCID,Shi Jiahua³^ORCID

Affiliation:

1. School of Pharmacy, Henan University, Kaifeng 475004, China

2. Department of Pharmacy, Shangqiu First People's Hospital, Shangqiu 476100, China

3. Key Laboratory of Natural Medicine and Immune-Engineering of Henan Province, Henan University, Kaifeng 475004, China

4. Department of Pharmacy, the First Affiliated Hospital of Henan University, Kaifeng 475001, China

5. Institute of Food Safety and Environment Monitoring, College of Chemistry, Fuzhou University, Fuzhou 350108, China

6. School of Public Health, Nantong Key Laboratory of Public Health and Medical Analysis, Nantong University, Nantong 226019, China

Abstract

A maximum GSH-depleting photodynamic nanosystem was developed by loading Cu2+ into porphyrin MOF. Both in vitro and in vivo results indicate MOF@Cu2+ could obliterate biofilm infection and facilitate wound healing with no distinct side effects.

Funder

National Natural Science Foundation of China

Henan Provincial Science and Technology Research Project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02577B

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