Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Author:

Pan Yuanbo1234ORCID,Tang Wei5,Fan Wenpei6,Zhang Jianmin123,Chen Xiaoyuan4789ORCID

Affiliation:

1. Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China

2. Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310009, Zhejiang, China

3. Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, 310009, China

4. Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore 119074, Singapore

5. Departments of Pharmacy and Diagnostic Radiology, Nanomedicine Translational Research Program, Faculty of Science and Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117544, Singapore

6. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, China

7. Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore

8. Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore

9. Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore

Abstract

Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing radiation to kill tumor cells.

Funder

National University of Singapore

National Natural Science Foundation of China

China Scholarship Council

Frontiers Center for Brain Science of the Ministry of Education

China Pharmaceutical University

Ministry of Education - Singapore

National Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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