Carbopol 940-based hydrogels loading synergistic combination of quercetin and luteolin from the herb Euphorbia humifusa to promote Staphylococcus aureus infected wound healing

Author:

Wu Xiying123ORCID,Chen Hao-Wei12,Zhao Ze-Yu12,Li Lisha3,Song Chi12,Xiong Juan2ORCID,Yang Guo-Xun2,Zhu Quangang3,Hu Jin-Feng12ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang 318000, China

2. Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China

3. Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China

Abstract

An optimized QU–LU Carbopol 940-based hydrogel significantly promoted S. aureus-infected wound healing through anti-infection, anti-inflammation, collagen deposition and angiogenesis, revealing it as a promising alternative for infected wound repair.

Funder

Key Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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