Synthesis and evaluation of WK-X-34 derivatives as P-glycoprotein (P-gp/ABCB1) inhibitors for reversing multidrug resistance-Reference-Cited by-同舟云学术

Synthesis and evaluation of WK-X-34 derivatives as P-glycoprotein (P-gp/ABCB1) inhibitors for reversing multidrug resistance

Author:

Cao Fei¹²,Li Yulong³,Ma Furong³,Wu Zumei³,Li Zheshen⁴,Chen Zhe-Sheng⁴^ORCID,Cheng Xiangdong¹⁵,Qin Jiang-Jiang¹⁵,Dong Jinyun¹⁵^ORCID

Affiliation:

1. Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China

2. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310032, China

3. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China

4. College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA

5. Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province, Hangzhou 310022, China

Abstract

Discovery of a novel P-gp inhibitor with high MDR reversal activity and low intrinsic cytotoxicity.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

Reference29 articles.