Effect of zwitterionic sulfobetaine incorporation on blood behaviours, phagocytosis, and in vivo biodistribution of pH-responsive micelles with positive charges

Author:

Wang Chengwei1ORCID,Liu Hao2,Lin Hu3,Zhong Rui4,Li Hao2,Liu Jiaxin4,Luo Xianglin3,Tian Meng2ORCID

Affiliation:

1. Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China

2. Department of Neurosurgery and Neurosurgery Research Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China

3. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, P. R. China

4. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu, 610052, P. R. China

Abstract

A series of pH-responsive and sulfobetaine-incorporated micelles with positive charges is prepared, in which the effects of the sulfobetaine incorporation displayed different profiles in the blood behaviours, phagocytosis, and in vivo biodistribution.

Funder

National Natural Science Foundation of China

Sichuan Province Science and Technology Support Program

Chinese Academy of Medical Sciences

Peking Union Medical College

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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