High-abundance peaks and peak clusters associate with pharmaceutical polymers and excipients in urinary untargeted clinical metabolomics data: exploration of their origin and possible impact on label-free quantification-Reference-Cited by-同舟云学术

High-abundance peaks and peak clusters associate with pharmaceutical polymers and excipients in urinary untargeted clinical metabolomics data: exploration of their origin and possible impact on label-free quantification

Published:2024 Issue: Volume: Page:
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Klont Frank¹²³^ORCID,Nijdam Fleur B.¹^ORCID,Bakker Stephan J. L.⁴,Keski-Rahkonen Pekka⁵,Hopfgartner Gérard³^ORCID,Investigators TransplantLines⁶

Affiliation:

1. Unit of PharmacoTherapy, -Epidemiology & -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

2. Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands

3. Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva, Quai Ernest Ansermet 24, 1211 Geneva, Switzerland

4. Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands

5. Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Avenue Tony Garnier 25, 69007 Lyon, France

6. Group of Authors on Behalf of the Transplant Lines Biobank and Cohort Study, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands

Abstract

Pharmaceutical polymers and excipients represent interesting but often overlooked chemical classes in clinical exposure and bioanalytical research.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Chiesi Farmaceutici

HORIZON EUROPE Marie Sklodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D3AN01874A

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