Synthesis and evaluation of novel N-3-benzimidazolephenylbisamide derivatives for antiproliferative and Hedgehog pathway inhibitory activity-Reference-Cited by-同舟云学术

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Synthesis and evaluation of novel N-3-benzimidazolephenylbisamide derivatives for antiproliferative and Hedgehog pathway inhibitory activity

Published:2015 Issue:6 Volume:6 Page:1137-1142
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sun Chiyu¹²³⁴⁵,Li Yangsheng¹²³⁴⁵,Shi Ailong¹²³⁴⁵,Zhang Jingzhou¹²³⁴⁵,Li Yafei¹²³⁴⁵,Zhao Mingming¹²³⁴⁵,Zhang Lijuan¹²³⁴⁵,Zheng Huachuan⁶⁷⁵,Meng Ying⁸⁹¹⁰⁵,Ding Huaiwei¹²³⁴⁵,Song Hongrui¹²³⁴⁵

Affiliation:

1. Key Laboratory of Structure-Based Drug Design and Discovery

2. Ministry of Education

3. Shenyang Pharmaceutical University

4. Shenyang 110016

5. PR China

6. The First Affiliated Hospital of Liaoning Medical University

7. Jinzhou 121001

8. College of Pharmacy

9. Liaoning University of Traditional Chinese Medicine

10. Dalian 116600

Abstract

7m, as a novel Hedgehog inhibitor, interacted closely with the smoothened receptor at the co-crystallized ligand (taledegib) site.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00092K

Reference43 articles.

1. Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents

2. Hedgehog pathway inhibitors: a patent review (2009 – present)

3. Hedgehog signaling pathway as a therapeutic target in various types of cancer

4. Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

5. Hedgehog signalling in cancer formation and maintenance

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2. Synthesis and Evaluation of Aminothiazole Derivatives as Hedgehog Pathway Inhibitors;Chemistry & Biodiversity;2019-11-12

3. Design of Hedgehog pathway inhibitors for cancer treatment;Medicinal Research Reviews;2018-11-28

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