Sargassum fusiforme fucoidan alleviates diet-induced insulin resistance by inhibiting colon-derived ceramide biosynthesis-Reference-Cited by-同舟云学术

Sargassum fusiforme fucoidan alleviates diet-induced insulin resistance by inhibiting colon-derived ceramide biosynthesis

Published:2021 Issue:18 Volume:12 Page:8440-8453
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zhang Ya¹²,Liu Jian¹,Mao Genxiang³^ORCID,Zuo Jihui¹,Li Shijun¹,Yang Yue¹,Thring Ronald W.²,Wu Mingjiang¹,Tong Haibin¹^ORCID

Affiliation:

1. College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China

2. Environmental Science and Environmental Engineering, University of Northern British Columbia, Prince George, BC, Canada

3. Zhejiang Provincial Key Lab of Geriatrics, Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, China

Abstract

Sargassum fusiforme fucoidan (SFF) remodels gut microbiota, enhances TUDCA content, inhibits the biosynthesis of colon-derived ceramide by blocking FXR signaling, restoring insulin sensitivity in DIO mice.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Science and Technology Plan Project of Wenzhou, China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO01272J

Reference50 articles.

1. FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes

2. Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

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