Epigallocatechin gallate-loaded tetrahedral DNA nanostructures as a novel inner ear drug delivery system

Author:

Chen Yuming123ORCID,Gu Jiayi123,Liu Yan45,Xu Ke123,Song Jie45ORCID,Wang Xueling123,Yu Dehong1236,Wu Hao123

Affiliation:

1. Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People's Republic of China

2. Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People's Republic of China

3. Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases(14DZ2260300), Shanghai 200011, People's Republic of China

4. Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China

5. Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences; The Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, People's Republic of China

6. Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, People's Republic of China

Abstract

Preparation of EGCG@TDNs and drug delivery to the inner ear for the treatment of noise-induced hearing loss.

Funder

Natural Science Foundation of Shanghai

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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