Iridium-catalyzed diacylmethylation of tyrosine and its peptides with sulfoxonium ylides-Reference-Cited by-同舟云学术

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Iridium-catalyzed diacylmethylation of tyrosine and its peptides with sulfoxonium ylides

Published:2024 Issue:59 Volume:60 Page:7622-7625
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Kharat Narendra Dinkar¹,Naharwal Sushma¹,Panda Siva S.²^ORCID,Bajaj Kiran³^ORCID,Sakhuja Rajeev¹^ORCID

Affiliation:

1. Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India

2. Department of Chemistry and Biochemistry & Department of Biochemistry and Molecular Biology, Augusta University, Augusta, GA 30912, USA

3. Department of Chemistry, Amity University, Noida, Uttar Pradesh, India

Abstract

Pyridyloxy-directed Ir(iii)-catalyzed diacylmethylation of protected tyrosines was achieved with alkyl and (hetero)aryl sulfoxonium ylides, furnishing tyrosine-based unnatural amino acids in good yields.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC02204A

Reference49 articles.

1. The Current State of Peptide Drug Discovery: Back to the Future?

2. Peptide-Based Vaccines: Current Progress and Future Challenges

3. Peptidomimetic toolbox for drug discovery

4. Deciphering the conformational landscape of few selected aromatic noncoded amino acids (NCAAs) for applications in rational design of peptide therapeutics

5. Designer tRNAs for efficient incorporation of non-canonical amino acids by the pyrrolysine system in mammalian cells

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