Tail-approach based design, synthesis, and cytotoxic evaluation of novel disubstituted and trisubstituted 1,3-thiazole benzenesulfonamide derivatives with suggested carbonic anhydrase IX inhibition mechanism-Reference-Cited by-同舟云学术

Tail-approach based design, synthesis, and cytotoxic evaluation of novel disubstituted and trisubstituted 1,3-thiazole benzenesulfonamide derivatives with suggested carbonic anhydrase IX inhibition mechanism

Published:2023 Issue:34 Volume:13 Page:24003-24022
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bondock Samir¹^ORCID,Albarqi Tallah¹,Abboud Mohamed¹,Nasr Tamer²³,Mohamed Nada M.³^ORCID,Abdou Moaz M.⁴^ORCID

Affiliation:

1. Chemistry Department, Faculty of Science, King Khalid University, 9004 Abha, Saudi Arabia

2. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795 Helwan, Cairo, Egypt

3. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information, MTI, 12055 Cairo, Egypt

4. Egyptian Petroleum Research Institute, Nasr City, 11727, Cairo, Egypt

Abstract

A novel series of 2,4,5- and 2,3,4-trisubstituted thiazole hybrids with 1,3,4-thiadiazolylbenzenesulfonamide was designed following the tail approach as possible hCAIX inhibitors.

Funder

King Khalid University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA02528D

Reference50 articles.

1. miR-141-3p suppresses development of clear cell renal cell carcinoma by regulating NEK6

2. Secosteroid–quinoline hybrids as new anticancer agents

3. Recent advances of thiazole hybrids in biological applications

4. Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

5. Thiazole-containing compounds as therapeutic targets for cancer therapy

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