Magnetic-nanowaxberry-based microfluidic ExoSIC for affinity and continuous separation of circulating exosomes towards cancer diagnosis

Author:

Ding Lihua12,Liu Xia1ORCID,Zhang Zhenzhong2,Liu Li-e1,He Sitian1,Wu Yan1,Effah Clement Yaw1ORCID,Yang Ruiying1ORCID,Zhang Aiai1,Chen Wensi1,Yarmamat Mubarak1,Qu Lingbo34,Yang Xiaonan5,Wu Yongjun1

Affiliation:

1. College of Public Health, Zhengzhou University, Zhengzhou 450001, China

2. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China

3. College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

4. Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, Zhengzhou University, Zhengzhou, 450001, China

5. School of Information Engineering, Zhengzhou University, Zhengzhou 450001, China

Abstract

A novel irregular serpentine channel microfluidic chip based on magnetic-nanowaxberry was developed to continuously separate plasma exosomes with large yield and optimum purity. It can be successfully applied to cancer diagnosis with high accuracy.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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