Efficient cocktail chemotherapy by co-delivery of a hydrogen sulfide-releasing aspirin prodrug and paclitaxel via single nanoparticles

Author:

Cai Lulu12345,He Lin12345,Wang Yan12345,Zhong Jian6785,Zhao Chengjian9101145,Zeng Shi9101145,Yu Jiying12345,Bian Yuan12345,Wei Yuquan9101145,Cai Wei1213145,Long Enwu12345,Jiao Pengcheng1516175,Yan Junfeng12345,Xu Quan12345ORCID

Affiliation:

1. Personalized Drug Therapy Key Laboratory of Sichuan Province

2. Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial

3. People's Hospital

4. Chengdu

5. P. R. China

6. School of Pharmacy

7. North Sichuan Medical College

8. Nanchong

9. State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy

10. West China Hospital

11. Sichuan University

12. State Key Laboratory of Heavy Oil Processing

13. China University of Petroleum (Beijing)

14. Beijing

15. Department of Civil and Environmental Engineering

16. Zhejiang University

17. Hangzhou 310000

Abstract

A cocktail composed of hydrogen sulfide-releasing aspirin (HS-ASP) and paclitaxel (PTX) in a single delivery system was formulated and provides a promising platform for the cocktail treatment of non-small cell lung cancer.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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