Natural triterpenoid-aided identification of the druggable interface of HMGB1 occupied by TLR4-Reference-Cited by-同舟云学术

Natural triterpenoid-aided identification of the druggable interface of HMGB1 occupied by TLR4

Published:2024 Issue:8 Volume:5 Page:751-762
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Shen Pingping¹,Jiang Xuewa¹,Kuang Yi¹,Wang Weiwei²,Raj Richa¹,Wang Wei³,Zhu Yuyuan⁴,Zhang Xiaochun⁵,Yu Boyang⁶,Zhang Jian¹⁶^ORCID

Affiliation:

1. Department of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China

2. Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210046, P. R. China

3. Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, IL, USA

4. The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China

5. School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, P. R. China

6. Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, P. R. China

Abstract

Using the unique triterpenoid probe, we found that the binding interface of HMGB1 was responsible for the recognition of TLR4 located on the “L” shaped B-box with K114 as a crucial hot-spot residue.

Funder

National Natural Science Foundation of China

Program for New Century Excellent Talents in University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D4CB00062E

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