Ir-catalyzed chemo- and enantioselective hydrogenation of enyne-conjugated ketones-Reference-Cited by-同舟云学术

Ir-catalyzed chemo- and enantioselective hydrogenation of enyne-conjugated ketones

Published:2024 Issue: Volume: Page:
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zheng Xuejuan¹²,Huang Fanping¹,Yu Jianfei¹,Lang Qiwei¹,Duan Ya-Nan³,Chen Gen-Qiang⁴^ORCID,Zhang Xumu¹³^ORCID

Affiliation:

1. Medi-X Pingshan, Guangdong Provincial Key Laboratory of Catalysis, and Department of Chemistry, Southern University of Science and Technology, Shenzhen, 518000, People's Republic of China

2. Shenzhen Grubbs Institute, Department of Chemistry, Southern University of Science and Technology, Shenzhen, 518000, People's Republic of China

3. Chemistry and Chemical Engineering Guangdong Laboratory, Shantou 515031, China

4. Academy for Advanced Interdisciplinary Studies and Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen 518000, People's Republic of China

Abstract

We herein report an efficient asymmetric hydrogenation of β-alkynyl α,β-unsaturated ketones by using Ir/f-phamidol as a catalyst under mild conditions, providing the corresponding chiral alcohols in up to 99% yield and 99% ee.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Commission

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO01362J

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4. Nickel‐Catalyzed Carbofluoroalkylation of 1,3‐Enynes to Access Structurally Diverse Fluoroalkylated Allenes

5. Copper-catalyzed functionalization of enynes