In situ mineralized PLGA/zwitterionic hydrogel composite scaffold enables high-efficiency rhBMP-2 release for critical-sized bone healing-Reference-Cited by-同舟云学术

In situ mineralized PLGA/zwitterionic hydrogel composite scaffold enables high-efficiency rhBMP-2 release for critical-sized bone healing

Published:2022 Issue:3 Volume:10 Page:781-793
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Liu Peiming¹²^ORCID,Bao Tianyi³,Sun Lian³,Wang Zeyi¹,Sun Jin¹,Peng Wan¹,Gan Donglin¹,Yin Guoyong³,Liu Pingsheng¹^ORCID,Zhang Wei-Bing³⁴,Shen Jian¹⁵

Affiliation:

1. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China

2. Changzhou Institute of Materia Medica Co., Ltd., Changzhou, Jiangsu 213000, China

3. Department of Orthopedics, Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, P. R. China

4. Department of Stomatology, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, China

5. Jiangsu Engineering Research Center of Interfacial Chemistry, Nanjing University, Nanjing 210093, P. R. China

Abstract

In situ mineralized PLGA/PSBMA scaffold enables high-efficiency sustained release of rhBMP-2 (only 1.7% within 35 days) and robust healing of critical-sized (5 mm) nonunion calvarial defects in rats with an ultralow dosage of rhBMP-2 (150 ng per scaffold).

Funder

National Natural Science Foundation of China

Six Talent Peaks Project in Jiangsu Province

Priority Academic Program Development of Jiangsu Higher Education Institutions

Nanjing Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D1BM01521D

Reference80 articles.