Diastereoselective access to [4,4]-carbospirocycles: governance of thermodynamic enolates with an organocatalyst in vinylogous cascade annulation-Reference-Cited by-同舟云学术

Diastereoselective access to [4,4]-carbospirocycles: governance of thermodynamic enolates with an organocatalyst in vinylogous cascade annulation

Published:2022 Issue:13 Volume:58 Page:2188-2191
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bhajammanavar Vinod¹,Mallik Sumitava¹,Choutipalli Venkata Surya Kumar²^ORCID,Subramanian Venkatesan²^ORCID,Baidya Mahiuddin¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India

2. Inorganic and Physical Chemistry Laboratory, CSIR-Central Leather Research Institute, Chennai 600 020, India

Abstract

A vinylogy concept driven highly diastereoselective cascade protocol towards [4,4]-carbospirocycles is developed by leveraging a spiro-annulation reaction through the thermodynamic enolate under organocatalysis.

Funder

Indian Institute of Technology Madras

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC06544K

Reference18 articles.

1. The Principle of Vinylogy.

2. The Vinylogous Aldol and Related Addition Reactions: Ten Years of Progress

3. α,α-Dicyanoalkenes: versatile vinylogous nucleophiles for organic synthesis

4. New Developments of the Principle of Vinylogy as Applied to π-Extended Enolate-Type Donor Systems

5. The use of spirocyclic scaffolds in drug discovery

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