Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy-hemoglobin oxidation

Author:

Dharmasivam Mahendiran12,Kaya Busra2,Wijesinghe Tharushi P.2,Richardson Vera2,Harmer Jeffrey R.3,Gonzalvez Miguel A.4ORCID,Lewis William5ORCID,Azad Mahan Gholam2,Bernhardt Paul V.4ORCID,Richardson Des R.126ORCID

Affiliation:

1. Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute, The University of Sydney, Sydney, New South Wales, 2006, Australia

2. Centre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, 4111, Australia

3. Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, 4072, Australia

4. School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, 4072, Australia

5. Department of Chemistry, University of Sydney, New South Wales, 2006, Australia

6. Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan

Abstract

The differential transmetallation of Dp4e4mT complexes provides valuable insights into their biological mechanism of action, off-target effects, and their potential therapeutic applications.

Funder

Griffith University

National Breast Cancer Foundation

National Health and Medical Research Council

Australian Research Council

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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