Dual-modal molecular imaging and therapeutic evaluation of coronary microvascular dysfunction using indocyanine green-doped targeted microbubbles

Author:

Awen Alimina1,Hu Dehong2,Gao Duyang2,Wang Zihang1,Wu Yayun2,Zheng Hairong2,Guan Lina1,Mu Yuming1ORCID,Sheng Zonghai2ORCID

Affiliation:

1. Department of Echocardiography, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Key Laboratory of Ultrasound Medicine, Urumqi, Xinjiang, 830011, P. R. China

2. Paul C. Lauterbur Research Center for Biomedical Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Key Laboratory of Ultrasound Imaging and Therapy, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, P. R. China

Abstract

We report ICG-doped targeted microbubbles as dual-modal probes for highly sensitive near-infrared fluorescence imaging and real-time ultrasound imaging of CMD in mouse models.

Funder

National Natural Science Foundation of China

CAS Key Laboratory of Health Informatics

Basic and Applied Basic Research Foundation of Guangdong Province

Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province

Science and Technology Planning Project of Shenzhen Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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