Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Author:

Li Haidong12ORCID,Kim Heejeong3ORCID,Xu Feng14,Han Jingjing3ORCID,Yao Qichao1,Wang Jingyun12ORCID,Pu Kanyi56ORCID,Peng Xiaojun17ORCID,Yoon Juyoung3ORCID

Affiliation:

1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China

2. School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China

3. Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea

4. The Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, China

5. School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637457, Singapore

6. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore

7. Research Institute of Dalian University of Technology in Shenzhen, Nanshan District, Shenzhen 518057, China

Abstract

In this review, we summarize the recent progress of activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold for detection, bioimaging, and diagnosis and therapy of diseases.

Funder

National Natural Science Foundation of China

National Research Foundation of Korea

Nanyang Technological University

Wenzhou Municipal Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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