Network modeling suggests HIV infection phenocopies PI3K-AKT pathway mutations to enhance HPV-associated cervical cancer

Author:

Olwal Charles Ochieng’12ORCID,Fabius Jacqueline M345,Zuliani-Alvarez Lorena3456,Eckhardt Manon346,Kyei George Boateng78,Quashie Peter Kojo1,Krogan Nevan J3456,Bouhaddou Mehdi491011,Bediako Yaw112

Affiliation:

1. West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana

2. Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana

3. The J. David Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA

4. Quantitative Biosciences Institute, University of California, San Francisco, CA, USA

5. The Cancer Cell Map Initiative, San Francisco and La Jolla, CA, USA

6. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA

7. Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana

8. University of Ghana Medical Centre, University of Ghana, Accra, Ghana

9. Institute for Quantitative and Computational Biosciences (QCBio), University of California, Los Angeles, LA, USA

10. Department of Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles, LA, USA

11. Molecular Biology Institute, University of California, Los Angeles, LA, USA

12. Yemaachi Biotech, Accra, Ghana

Abstract

Network modeling suggests the inflammatory factors secreted due to HIV infection, even in the presence of antiretroviral therapy, activate PI3K-AKT signaling in cervical cells and accelerate cervical cancer progression in HPV/HIV coinfected women.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

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