Chondrocyte secretome enriched microparticles encapsulated with the chondrocyte membrane to facilitate the chondrogenesis of BMSCs and reduce hypertrophy

Author:

Tang Zizhao12,Lu Yan12,Zhang Shixin12,Wang Jing3,Wang Qiguang12ORCID,Xiao Yumei12ORCID,Zhang Xingdong12

Affiliation:

1. National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, 610065, China

2. College of Biomedical Engineering, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, 610065, China

3. College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu, Sichuan, 610059, China

Abstract

The “artificial chondrocytes” that consist of chondrocyte secretome enriched PLGA microparticles with the encapsulation of chondrocytes’ membrane fragments had facilitated chondrogenesis and reduced hypertrophy of BMSCs in vitro and in vivo.

Funder

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

National Key Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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