Sclareol prevents ovariectomy-induced bone loss in vivo and inhibits osteoclastogenesis in vitro via suppressing NF-κB and MAPK/ERK signaling pathways

Author:

Jin Haiming12345,Shao Zhenxuan12346,Wang Qingqing12345,Miao Jiansen6734,Bai Xueqin8934,Liu Qian1011124,Qiu Heng5131415,Wang Chao5131415,Zhang Zengjie12346,Jennifer Tickner5131415,Wang Xiangyang1234,Xu Jiake12345ORCID

Affiliation:

1. Key Laboratory of Orthopaedics of Zhejiang Province

2. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical Universtiy

3. Wenzhou

4. China

5. School of Biomedical Sciences

6. The Second School of Medicine

7. Wenzhou Medical University

8. Department of Radiology

9. First Affiliated Hospital of Wenzhou Medical University

10. Research Centre for Regenerative Medicine and Guangxi Key Laboratory of Regenerative Medicine

11. Guangxi Medical University

12. Guangxi

13. The University of Western Australia

14. Perth

15. Western Australia

Abstract

Postmenopausal osteoporosis (PMO) is a progressive disease occurring in elderly postmenopausal women that is characterized by low bone mass and impaired bone quality.

Funder

Arthritis Foundation of Australia

University of Western Australia

National Health and Medical Research Council

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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