SN- and NS-puckered sugar conformers are precursors of the (6–4) photoproduct in thymine dinucleotide-Reference-Cited by-同舟云学术

SN- and NS-puckered sugar conformers are precursors of the (6–4) photoproduct in thymine dinucleotide

Published:2022 Issue:11 Volume:20 Page:2300-2307
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Jakhlal Jouda¹,Denhez Clément¹²,Coantic-Castex Stéphanie¹,Martinez Agathe³,Harakat Dominique³,Douki Thierry⁴^ORCID,Guillaume Dominique¹,Clivio Pascale¹^ORCID

Affiliation:

1. Université de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, UFR de Pharmacie, 51100 Reims, France

2. MaSCA, P3M, UFR des Sciences Exactes et Naturelles, 51100 Reims, France

3. Université de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, UFR des Sciences Exactes et Naturelles, 51100 Reims, France

4. Université Grenoble Alpes, CEA, CNRS, IRIG, SyMMES, 38000 Grenoble, France

Abstract

The S conformation of at least one sugar residue in the TT site is crucial for (6–4) PP formation. This S sugar can be located at the 5′- or 3′-end of the TT site. The 5′-end S conformer location is the most efficient at providing (6–4) PP.

Funder

Centre National de la Recherche Scientifique

Ministère de l'Enseignement Supérieur et de la Recherche

Fondation pour la Recherche Médicale

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00044J

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