Hybrid system {W6I8}-cluster/dsDNA as an agent for targeted X-ray induced photodynamic therapy of cancer stem cells

Author:

Pozmogova Tatiana N.123,Sitnikova Natalya A.1,Pronina Ekaterina V.3,Miroshnichenko Svetlana M.14,Kushnarenko Andrey O.1,Solovieva Anastasiya O.1,Bogachev Sergey S.5,Vavilov Georgy D.6ORCID,Efremova Olga A.1,Vorotnikov Yuri A.3ORCID,Shestopalov Michael A.3ORCID

Affiliation:

1. Research Institute of Clinical and Experimental Lymphology – Branch of the ICG SB RAS, 2 Timakova st., 630060 Novosibirsk, Russian Federation

2. Novosibirsk State University, 2 Pirogova st., 630090 Novosibirsk, Russian Federation

3. Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., 630090 Novosibirsk, Russian Federation

4. Federal Research Centre for Basic and Translational Medicine, 2 Timakova st., 630060 Novosibirsk, Russian Federation

5. Institute of Cytology and Genetics, SB RAS, 10 Acad. Lavrentiev Ave., 630090 Novosibirsk, Russian Federation

6. National Medical Research Center for Circulation Pathology n.a. Academician E.N. Meshalkin, 15 Rechkunovskaya st., 630055 Novosibirsk, Russian Federation

Abstract

The hybrid material W6-cluster/dsDNA designed here demonstrates selective penetration into cancer stem cells and their targeted elimination using X-PDT.

Funder

Russian Science Foundation

Russian Foundation for Basic Research

Ministry of Education and Science of the Russian Federation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Materials Science

Reference42 articles.

1. World Health Organization, Cancer, ( https://www.who.int/news-room/fact-sheets/detail/cancer )

2. World Cancer Report 2014, World Health Organization, Geneva, Switzerland, 2014

3. Molecular principles of metastasis: a hallmark of cancer revisited

4. Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance

5. Metastatic Cancer Cell

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