Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors-Reference-Cited by-全球学者库

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

Published:2020 Issue:36 Volume:11 Page:9904-9909
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sargsyan Karen¹²³⁴^ORCID,Lin Chien-Chu⁵²³⁴^ORCID,Chen Ting¹²³⁴^ORCID,Grauffel Cédric¹²³⁴^ORCID,Chen Yi-Ping⁵²³⁴,Yang Wei-Zen⁵²³⁴,Yuan Hanna S.⁵²³⁴^ORCID,Lim Carmay¹²³⁴⁶^ORCID

Affiliation:

1. Institute of Biomedical Sciences

2. Academia Sinica

3. Taipei 115

4. Taiwan

5. Institute of Molecular Biology

6. Department of Chemistry

Abstract

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Funder

Ministry of Science and Technology, Taiwan

Academia Sinica

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC02646H

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1. Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

2. Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-κB and Induction of Antiviral Response in Epithelial Cells